1462Bronchoalveolar Lavage Lateral-Flow Device Test for Diagnosing Invasive Pulmonary Aspergillosis in ICU patients: a multicenter study
نویسندگان
چکیده
Invasive Pulmonary Aspergillosis in ICU patients: a multicenter study Martin Hoenigl, MD; Jürgen Prattes, MD; Susanne Eigl, MD; Cornelia Lass-Flörl, MD; Birgit Willinger, MD; Frederike Reischies; Verena Posch; Michaela Lackner PHD; Holger Flick, MD; Katharina Hönigl; Christoph Koidl; Christopher Thornton PHD; Robert Krause, MD; Section of Infectious Diseases, Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Medical University of Graz, Graz, Austria; Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Graz, Austria; Institute of Hygiene and Social Medicine, Innsbruck, Austria; Medical University of Vienna, Vienna, Austria; Innsbruck Medical University, Innsbruck, Austria; Divison of Pulmonology, Medical University of Graz, Graz, Austria; Institute of Hygiene, Medical University of Graz, Graz, Austria; Biosciences, University of Exeter, Exeter, United Kingdom
منابع مشابه
Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients
INTRODUCTION The incidence of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is increasing, and early diagnosis of the disease and treatment with antifungal drugs is critical for patient survival. Serum biomarker tests for IPA typically give false-negative results in non-neutropenic patients, and galactomannan (GM) detection, the preferred diagnostic test for IPA u...
متن کاملComments on \'\'Detection of galactomannan in the bronchoalveolar lavage of high-risk patients with invasive aspergillosis admitted at the intensive care unit\'\' by Khodavaisy et al.
Comments on ''Detection of galactomannan in the bronchoalveolar lavage of high-risk patients with invasive aspergillosis admitted at the intensive care unit'' by Khodavaisy et al. AWT-SEP AWT-SEP AWT-SEP AWT-SEP AWT-SEP AWT-SEP Galactomannan in bronchoalveolar lavage for diagnosis of invasive aspergillosis We rea...
متن کاملDetection of galactomannan in bronchoalveolar lavage of the intensive care unit patients at risk for invasive aspergillosis
Background and Purpose: Invasive aspergillosis (IA) is one of the most common life-threatening fungal infections among the critically ill patients including intensive care unit (ICU) patients. Delayed diagnosis and therapy may lead to poor outcomes. Diagnosis may be facilitated by a test for molecular biomarkers, i.e. detection of galactomannan (GM) antigen based on enzyme immunoassay, which is...
متن کاملPerformance of galactomannan, beta-d-glucan, Aspergillus lateral-flow device, conventional culture, and PCR tests with bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis.
Galactomannan detection in bronchoalveolar lavage (BAL) fluid samples (GM test) is currently considered the gold standard test for diagnosing invasive pulmonary aspergillosis (IPA). The limitations, however, are the various turnaround times and availability of testing. We compared the performance of GM testing with that of conventional culture, an Aspergillus lateral-flow-device (LFD) test, a b...
متن کاملBronchoalveolar lavage lateral-flow device test for invasive pulmonary aspergillosis in solid organ transplant patients: a semiprospective multicenter study.
BACKGROUND Invasive pulmonary aspergillosis (IPA) remains an important cause of morbidity and mortality among patients undergoing solid organ transplantation (SOT). Because of the crude mortality of 80% to 90% in the absence of adequate treatment, timely diagnosis and early intervention with antifungal drugs are key factors in the successful treatment of IPA. Diagnosis, however, remains difficu...
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